Istanbulspor lost 1-0 to Manisa Futbol Kulübü in the 22nd week of the 1. Lig. The match took place at Manisa 19 Mayıs Stadium. The home team took the lead in the 35th minute with a goal from Yusuf Talum. Despite a strong performance throughout the match, Istanbulspor struggled to find the net. In the 39th minute, a goal by Emir Kaan was disallowed after a VAR review. The first half ended with Manisa FK leading 1-0. In the second half, Istanbulspor earned a penalty in the 48th minute, but Emir Kaan's shot was saved by goalkeeper Vedat. Towards the end of the match, in the 90+7th minute, Manisa FK's Yusuf received a red card after a second yellow for a foul on Vorobjovas. As a result, Manisa FK defeated Istanbulspor 1-0, reaching 30 points.